Walter Jakob Gehring (1939-2014)

نویسندگان

  • Jakob Gehring
  • Walter Jakob Gehring
  • Ernst Hadorn
چکیده

Walter Jakob Gehring [3] discovered the homeobox [4], a DNA segment found in a specific cluster of genes [5] that determine the body plan of animals, plants, and fungi. Gehring identified the homeobox [4] in 1983, with the help of colleagues while isolating the Antennapedia (Antp) gene in fruit flies (Drosophila [6]) at the University of Basel [7] in Basel, Switzerland. Hox genes [8], a family of genes [5] that contain the homeobox [4] sequence, determine the head-to-tail (anterior-posterior) body axis of both vertebrates and invertebrates. Gehring also identified the homeobox [4]-containing Pax-6 gene as the master control gene in eye development of Drosophila [9], the same gene that, when mutated or absent in humans [10], leads to aniridia, or lack of the iris, in humans [10]. Gehring's work with the homeobox [4] suggested to biologists that widely different species share a similar and evolutionarily conserved genetic pathway that controls the development of overall body plans, from fruit flies to humans [10].

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Obituary: Walter J. Gehring (1939-2014).

Alex Schier looks back at the life and research of his graduate mentor and friend Walter Gehring.

متن کامل

In memoriam: A man for all eyes-Walter Gehring, 1939-2014

Developmental biologists eagerly desired to understand the molecular basis of development. The discovery of the Homeo domain in homeotic genes in Drosophila provided the means whereby a new era dawned in the field. Walter Gehring and his colleagues stunned the scientific world by identifying this 60-amino acid domain with DNA binding activity [1]. Soon, homeobox-containing genes were found in a...

متن کامل

Walter Jakob Gehring: A master of developmental biology.

With Walter J. Gehring’s death in Basel on May 29, 2014, the scientific community lost one of the pioneers of molecular developmental biology. Walter will be missed by a large community of friends and colleagues, but he lives on in the work of the many scientists whom he had mentored and who now work in his and related fields. Walter J. Gehring, born in Zurich in 1939, became interested in deve...

متن کامل

From transdetermination to the homeodomain at atomic resolution. An interview with Walter J. Gehring.

Since the Swiss zoologist Ernst Hadorn first realized in the late 1940s that genes are crucial to the development of the fruit fly Drosophila melanogaster (and any other organism, that is), the field of developmental biology has undergone some dramatic changes. Before Hadorn’s revelation, genes were thought to be responsible only for traits such as eye colour or wing shape. In the early 1970s, ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2017